Resting-state functional reorganization of the rat limbic system following neuropathic injury

CORRIGENDUM: Resting-state functional reorganization of the rat limbic system following neuropathic injury

Resting-sate functional reorganization of the rat limbic system following neuropathic injury

Human brain imaging studies from various clinical cohorts show that chronic pain is associated with large-scale brain functional and morphological reorganization. However, how the rat whole-brain network is topologically reorganized to support persistent pain-like behavior following neuropathic injury remains unknown. Here we compare resting state fMRI functional connectivity-based whole-brain ...

Nervous system reorganization following injury.

Contrary to the classical view of a pre-determined wiring pattern, there is considerable evidence that cortical representation of body parts is continuously modulated in response to activity, behavior and skill acquisition. Both animal and human studies showed that following injury of the peripheral nervous system such as nerve injury or amputation, the somatosensory cortex that responded to th...

Resting-State Functional Connectivity in Rat Brain

Introduction Synchronized low-frequency fluctuations in resting-state fMRI (1) have been used to investigate functional connectivity between brain areas. Recent studies demonstrate that this technique can be utilized in the study of Alzheimer’s disease (2), antidepressant effects (3), and “default mode” of brain networks (4). So far, most resting-state fMRI studies have been performed on humans...

Altered Resting State in Diabetic Neuropathic Pain

BACKGROUND The spontaneous component of neuropathic pain (NP) has not been explored sufficiently with neuroimaging techniques, given the difficulty to coax out the brain components that sustain background ongoing pain. Here, we address for the first time the correlates of this component in an fMRI study of a group of eight patients suffering from diabetic neuropathic pain and eight healthy cont...